期刊
JOURNAL OF BURN CARE & RESEARCH
卷 31, 期 1, 页码 158-175出版社
OXFORD UNIV PRESS
DOI: 10.1097/BCR.0b013e3181c7ed82
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资金
- National Institutes of Health [NIH R01-HL41272]
- Department of Veterans' Affairs
- American Heart Association [AHA 0815674G]
- Falk Medical Research Trust
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL041272] Funding Source: NIH RePORTER
Angiogenesis, or the formation of new blood vessels from the preexisting vasculature, is a key component in numerous physiologic and pathologic responses and has broad impact in many medical and surgical specialties. In this review, we discuss the key cellular steps that lead to the neovascularization of tissues and highlight the main molecular mechanisms and mediators in this process. We include discussions on proteolytic enzymes, cell-matrix interactions, and pertinent cell signaling pathways and end with a survey of the mechanisms that lead to the stabilization and maturation of neovasculatures. (J Burn Care Res 2010;31:158-175)
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