期刊
NEUROBIOLOGY OF AGING
卷 36, 期 3, 页码 1424-1434出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2014.12.025
关键词
Cognitive reserve; Verbal working memory; Neural efficiency; Event-related potentials (ERPs); P3; Cognitive aging
资金
- start-up funds
- UMass Dartmouth Chancellor's Research Grant
- UMass Joseph Healey Endowment Grant by University of Massachusetts, Dartmouth
Although many epidemiological studies suggest the beneficial effects of higher cognitive reserve (CR) in reducing age-related cognitive decline and dementia risk, the neural basis of CR is poorly understood. To our knowledge, the present study represents the first electrophysiological investigation of the relationship between CR and neural reserve (i.e., neural efficiency and capacity). Specifically, we examined whether CR modulates event-related potentials associated with performance on a verbal recognition memory task with 3 set sizes (1, 4, or 7 letters) in healthy younger and older adults. Neural data showed that as task difficulty increased, the amplitude of the parietal P3b component during the probe phase decreased and its latency increased. Notably, the degree of these neural changes was negatively correlated with CR in both age groups, such that individuals with higher CR showed smaller changes in P3b amplitude and less slowing in P3b latency (i.e., smaller changes in the speed of neural processing) with increasing task difficulty, suggesting greater neural efficiency. These CR-related differences in neural efficiency may underlie reserve against neuropathology and age-related burden. (C) 2015 Elsevier Inc. All rights reserved.
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