αB-Crystallin is a Novel Oncoprotein Associated with Poor Prognosis in Breast Cancer

Purpose: alpha B-crystallin, a small heat shock protein, is an antiapoptotic protein associated with aggressive tumor behavior. A recent study revealed that alpha B-crystallin is overexpressed in a metastatic variant of the GI101A human breast carcinoma cell line. The purpose of this study was to investigate whether alpha B-crystallin is related to other breast tumor markers and can predict a breast cancer prognosis. Methods: Eighty-two patients who underwent breast cancer surgery at Hallym Sacred Heart Hospital were enrolled. alpha B-crystallin expression was determined by immunohistochemical staining. Estrogen receptor, progesterone receptor (PR), human epidermal growth factor receptor, lymphovascular invasion, histological grade, other tumor markers and time to recurrence were compared with alpha B-crystallin expression. Results: alpha B-crystallin expression in breast cancer tissues was associated with PR (p=0.030), the number of metastatic lymph nodes (pN) (p = 0.020), lymphovascular invasion (p=0.022), histological grade (p=0.004) and triple negative breast cancer (TNBC) (p=0.004). alpha B-crystallin expression significantly decreased time to recurrence (p = 0.039). Conclusion: The results revealed a strong relationship between alpha B-crystallin and poor prognostic factors such as the number of metastatic lymph nodes (especially pN2), TNBC, and rapid time to recurrence. We believe that alpha B-crystallin could be a novel oncoprotein biomarker of a poor prognosis in breast cancer.