期刊
JOURNAL OF BONE AND MINERAL RESEARCH
卷 27, 期 3, 页码 687-693出版社
WILEY
DOI: 10.1002/jbmr.1472
关键词
DENOSUMAB; BONE MINERAL DENSITY; FRACTURE; SURROGATE; PERCENT OF TREATMENT EFFECT EXPLAINED
资金
- Amgen Inc.
- Servier
- Novartis
- Amgen
- Roche
- Eli Lilly
- Schering Plough
- Pfizer
- Wyeth-Ayerst
- Novo Nordisk
- Procter Gamble
- Groupe Fournier
- Besins EscoVesco
- MSD
- Chiesi
- Boehringer Mannheim
- AstraZeneca
- California Pacific Medical Center
- GlaxoSmithKline
- Hologic
- Kyphon Inc.
- Lilly Industries
- Maxygen
- Nastech Pharmaceuticals
- Nestle Research Center
- New Zealand Milk Limited
- ONO-Pharma
- Organon Laboratories
- Osteologix
- Procter & Gamble Pharmaceuticals
- Diagnostics
- Sanofi-Aventis
- Shire
- Tethys
- Trans-Pharma Medical Limited
- Unilever
- Unipath
- Merck
- Boehringer
- JJ
- GSK
- Biosante
- Lilly
- Takeda
- Warner-Chilcott
- Fund for Scientific Research, Flanders, Belgium (FWO-Vlaanderen)
Dual-energy X-ray absorptiometric bone mineral density (DXA BMD) is a strong predictor of fracture risk in untreated patients. However, previous patient-level studies suggest that BMD changes explain little of the fracture risk reduction observed with osteoporosis treatment. We investigated the relevance of DXA BMD changes as a predictor for fracture risk reduction using data from the FREEDOM trial, which randomly assigned placebo or denosumab 60?mg every 6 months to 7808 women aged 60 to 90 years with a spine or total hip BMD T-score?100%] and 72% [95% CI: 24% >100%], respectively). Previous patient-level studies may have underestimated the strength of the relationship between BMD change and the effect of treatment on fracture risk or this relationship may be unique to denosumab. (c) 2012 American Society for Bone and Mineral Research
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