期刊
JOURNAL OF BONE AND MINERAL RESEARCH
卷 27, 期 10, 页码 2217-2222出版社
WILEY-BLACKWELL
DOI: 10.1002/jbmr.1660
关键词
PRIMARY ALDOSTERONISM; ADRENAL INCIDENTALOMA; OSTEOPOROSIS; VERTEBRAL FRACTURES; URINARY CALCIUM EXCRETION
In rats with aldosteronism, a reduction of bone mineral density (BMD) and cortical bone strength has been reported. Our study was aimed to evaluate bone involvement in patients with primary aldosteronism (PA). A total of 188 consecutive subjects with adrenal incidentaloma, observed between November 2009 and October 2011, were screened for PA with aldosterone-to-renin ratio. After confirmatory tests, in those who screened positive, 11 patients were diagnosed as PA and 15 patients were not (nPA). A serum/urinary biochemical profile, parathyroid hormone (PTH), BMD measured at lumbar spine (LS) and total and femoral neck (TN and FN) by dual X-ray absorptiometry, and conventional spinal radiographs (T4L4) were obtained in all subjects. PA patients had a significantly higher 24-hour urinary calcium (6.28?+/-?1.85 versus 4.28?+/-?1.18?mmol/d; p?
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