期刊
JOURNAL OF BONE AND MINERAL RESEARCH
卷 27, 期 1, 页码 119-124出版社
WILEY-BLACKWELL
DOI: 10.1002/jbmr.506
关键词
BONE DENSITOMETRY; BONE QCT; BODY COMPOSITION
资金
- NIDDK NIH HHS [T32 DK007028, K23 DK093713] Funding Source: Medline
Major alterations in body composition, such as with obesity and weight loss, have complex effects on the measurement of bone mineral density (BMD) by dual-energy X-ray absorptiometry (DXA). The effects of altered body fat on quantitative computed tomography (QCT) measurements are unknown. We scanned a spine phantom by DXA and QCT before and after surrounding with sequential fat layers (up to 12kg). In addition, we measured lumbar spine and proximal femur BMD by DXA and trabecular spine BMD by QCT in 13 adult volunteers before and after a simulated 7.5kg increase in body fat. With the spine phantom, DXA BMD increased linearly with sequential fat layering at the normal (P<0.01) and osteopenic (p<0.01) levels, but QCT BMD did not change significantly. In humans, fat layering significantly reduced DXA spine BMD values (mean +/- SD: -2.2 +/- 3.7%, p=0.05) and increased the variability of measurements. In contrast, fat layering increased QCT spine BMD in humans (mean +/- SD: 1.5 +/- 2.5%, p=0.05). Fat layering did not change mean DXA BMD of the femoral neck or total hip in humans significantly, but measurements became less precise. Associations between baseline and fat-simulation scans were stronger for QCT of the spine (r2=0.97) than for DXA of the spine (r2=0.87), total hip (r2=0.80), or femoral neck (r2=0.75). Bland-Altman plots revealed that fat-associated errors were greater for DXA spine and hip BMD than for QCT trabecular spine BMD. Fat layering introduces error and decreases the reproducibility of DXA spine and hip BMD measurements in human volunteers. Although overlying fat also affects QCT BMD measurements, the error is smaller and more uniform than with DXA BMD. Caution must be used when interpreting BMD changes in humans whose body composition is changing. (C) 2012 American Society for Bone and Mineral Research
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据