期刊
JOURNAL OF BONE AND MINERAL RESEARCH
卷 24, 期 5, 页码 899-907出版社
WILEY
DOI: 10.1359/JBMR.081232
关键词
nonunion; bone; allograft; autograft; biomechanics; mu CT
资金
- NIAMS NIH HHS [AR053459, AR48681, R01 AR051469, T32 AR053459, R01 AR048681, AR054041, AR51469, P50 AR054041] Funding Source: Medline
- NIDCR NIH HHS [DE017096, R21 DE017096-01A1, R21 DE017096] Funding Source: Medline
Evaluation of structural bone grafts risk of failure requires noninvasive quantitative predictors of functional strength. We hypothesized that a quantitative graft-to-host union biometric would correlate significantly with biomechanical properties as a surrogate for the risk of fracture. To test this, we developed a novel algorithm to compute the union between host callus and graft, which was termed the union ratio. We compared the union ratio of live autografts to devitalized allografts implanted into the mid-diaphysis of mouse femurs for 6 and 9 wk. Surprisingly, the autograft union ratio decreased from 0.228 +/- 0.029 at 6 wk to 0.15 +/- 0.011 at 9 wk (p < 0.05) and did not correlate with the torsional properties of the autografts. The allograft union ratio was 0.105 +/- 0.023 at 6 wk but increased to 0.224 +/- 0.029 at 9 wk (p < 0.05). As a single variable, the union ratio correlated significantly with ultimate torque (R-2 = 0.58) and torsional rigidity (R-2 = 0.51) of the allografts. Multivariable regression analyses of allografts that included the union ratio, the graft bone volume, the maximum and minimum polar moment of inertia, and their first-order interaction terms with the union ratio as independent variables resulted in significant correlations with the ultimate torque and torsional rigidity (adjusted R-2 = 0.80 and 0.89. respectively). These results suggest that, unlike live autografts, the union between the devitalized allograft and host contributes significantly to the strength of grafted bone. The union ratio has important clinical implications as a novel biometric for noninvasive assessment of functional strength and failure risk.
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