期刊
JOURNAL OF BONE AND MINERAL RESEARCH
卷 25, 期 1, 页码 114-123出版社
WILEY
DOI: 10.1359/jbmr.090708
关键词
BONE REPAIR; AGING; TNF; CYTOKINE
资金
- NIH [AA012223]
- NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM [R01AA012223] Funding Source: NIH RePORTER
Skeletal changes accompanying aging are associated with both increased risk of fractures and impaired fracture healing, which, in turn, is due to compromised bone regeneration potential. These changes are associated with increased serum levels of selected pro-inflammatory cytokines, e.g., tumor necrosis factor alpha (TNF-alpha). We have used a unique model of bone regeneration to demonstrate (1) that aged-related deficits in direct bone formation can be restored to young mice by treatment with TNF blockers and (2) that the cyclin-dependent kinase inhibitor p21 is a candidate for mediation of the osteoinhibitory effects of TNF. It has been hypothesized recently that TNF antagonists may represent novel anabolic agents, and we believe that the data presented here represent a successful test of this hypothesis. (C) 2010 American Society for Bone and Mineral Research.
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