期刊
JOURNAL OF BONE AND MINERAL METABOLISM
卷 30, 期 4, 页码 400-407出版社
SPRINGER JAPAN KK
DOI: 10.1007/s00774-011-0328-y
关键词
Bone mineral density; Osteoporosis; Spinal cord injury; Sciatic nerve resection
In the present study, we examined intraosseous blood vessel parameters of the tibial metaphysis in mice using microcomputed tomography (A mu CT) to investigate the relationship between post-nerve-injury osteoporosis and local intraosseous blood vessel volume and number. Mice were randomly divided into groups receiving spinal cord injury (SCI), sciatic nerve resection group (NX), or intact controls (30 mice/group). Four weeks after surgery, mice were perfused with silicone and the distribution of intraosseous blood vessels analyzed by mu CT. The bone density, mu CT microstructure, biomechanical properties, and the immunohistochemical and biochemical indicators of angiogenesis were also measured. The SCI group showed significantly reduced tibial metaphysis bone density, mu CT bone microstructure, tibial biomechanical properties, indicators of angiogenesis, and intraosseous blood vessel parameters compared to the NX group. Furthermore, the spinal cord-injured mice exhibited significantly decreased intraosseous blood vessel volume and number during the development of osteoporosis. In conclusion, these data suggest that decreased intraosseous blood vessel volume and number may play an important role in the development of post-nerve-injury osteoporosis.
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