期刊
JOURNAL OF BIOTECHNOLOGY
卷 163, 期 2, 页码 112-123出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jbiotec.2012.06.024
关键词
Filamentous microorganisms; Morphology; Mycel and pellet growth; Image analysis; Rheology; Environome
资金
- German Research Foundation (DFG) through the Collaborative Research Center [SFB 578]
- Allianz Industrie Forschung Micro-particle based cultivation of filamentous fungi [16926/N]
Filamentous fungi have been widely applied in industrial biotechnology for many decades. In submerged culture processes, they typically exhibit a complex morphological life cycle that is related to production performance - a link that is of high interest for process optimization. The fungal forms can vary from dense spherical pellets to viscous mycelia. The resulting morphology has been shown to be influenced strongly by process parameters, including power input through stirring and aeration, mass transfer characteristics, pH value, osmolality and the presence of solid micro-particles. The surface properties of fungal spores and hyphae also play a role. Due to their high industrial relevance, the past years have seen a substantial development of tools and techniques to characterize the growth of fungi and obtain quantitative estimates on their morphological properties. Based on the novel insights available from such studies, more recent studies have been aimed at the precise control of morphology, i.e., morphology engineering, to produce superior bio-processes with filamentous fungi. (C) 2012 Elsevier B.V. All rights reserved.
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