期刊
NEURO-ONCOLOGY
卷 18, 期 2, 页码 275-282出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/neuonc/nov168
关键词
bevacizumab; DCE-MRI; neurofibromatosis type 2; prediction; treatment response
资金
- Cancer Research UK (CRUK) [C8742/A18097]
- Engineering and Physical Sciences Research Council (EPSRC) [C8742/A18097]
- Cancer Research UK [16465, 18097] Funding Source: researchfish
- National Institute for Health Research [NF-SI-0509-10214] Funding Source: researchfish
Antiangiogenic therapy of vestibular schwannoma (VS) in type 2 neurofibromatosis can produce tumor shrinkage with response rates of 40%-60%. This study examines the predictive value of parameter-derived MRI in this setting. Twelve patients with 20 VSs were recruited. Each had at least one rapidly growing tumor. Patients were treated with bevacizumab, 5 mg/kg every 2 weeks. Patients with stable or reduced VS volume were maintained at 2.5-5 mg every 4 weeks after 6 months. Those who failed treatment had their bevacizumab discontinued. Dynamic contrast-enhanced (DCE) MRI performed prior to treatment using a high temporal resolution technique, and data were analyzed to allow measurement of contrast transfer coefficient (K-trans), vascular fraction (v(p)), extravascular-extracellular fraction (v(e)). Relaxation rate (R1(N)) was measured using a variable flip angle technique. Apparent diffusional coefficient (ADC) was calculated from diffusion-weighted imaging. The predictive power of microvascular parameters and ADC were examined using logistic regression modeling. Responding tumors were larger (P < .001), had lower R1(N) (P < .001), and higher K-trans (P < .05) and ADC (P < .01). They showed increases in R1(N) (P < .01) and reduction of K-trans (P < .01) and ADC (P < .01). Modeling to predict response demonstrated significant independent predictive power for R1(N) (I' = - 0.327, P < .001), and K-trans (I' = 0.156, P < .05). Modeling to predict percentage change in tumor volume at 90 days identified baseline tumor volume (I' = 5.503, P < .05), R1(N) (I' = - 5.844, P < .05), and K-trans (I' = 5.622, P < .05) as independent significant predictors. In patients with type 2 neurofibromatosis, biomarkers from DCE-MRI are predictive of VS volume response to inhibition of vascular endothelial growth factor inhibition.
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