期刊
JOURNAL OF BIOTECHNOLOGY
卷 161, 期 2, 页码 121-125出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jbiotec.2012.05.019
关键词
Mirror image phage display; D-enantiomeric peptide; Pharmaceutical biotechnology; Drug discovery
资金
- CLIB-Graduate Cluster Industrial Biotechnology
Peptides are attracting increasing attention as therapeutics. D-enantiomeric peptides are remarkably resistant to in vivo proteolysis and elicit low immunogenic responses when compared with the respective L-peptides. Therefore, D-peptides can serve as therapeutic and early diagnosis agents for drug development. Here we discuss the application of mirror image phage display in pharmaceutical biotechnology aiming to identify protease resistant D-peptides with biotechnological approaches. (C) 2012 Elsevier B. V. All rights reserved.
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