期刊
JOURNAL OF BIOTECHNOLOGY
卷 161, 期 2, 页码 147-152出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jbiotec.2012.04.004
关键词
ABE; Clostridium acetobutylicum; Two-stage continuous fermentation; Repeated fed-batch; Specific product rate; Volumetric productivity
资金
- Ministry of Innovation, Science and Research of North Rhine-Westphalia in the frame of CLIB - Graduate Cluster Industrial Biotechnology [314 108 001 08]
In comparison to the different fermentation modes for the production of acetone, butanol and ethanol (ABE) researched to date, the continuous fermentation is the most economically favored. Continuous fermentation with two or more reactor cascade is reported to be the most efficient as it results in a more stable solvent production process. In this work, it is shown that a continuous (first-stage) reactor coupled to a repeated fed-batch (second stage) is superior to batch and fed-batch fermentations, including two-stage continuous fermentation. This is due to the efficient catalyst use, reported through the specific product rate and rapid glucose consumption rate. High solvents are produced at 19.4 g(ABE) l(-1), with volumetric productivities of 0.92 g(butanol) l(-1) h(-1) and 1.47 g(ABE) l(-1) h(-1). The bioreactor specific productivities of 0.62 and 0.39 g g(-1) (cdw) h(-1) obtained show a high catalyst activity. This new process mode has not been reported before in the development of ABE fermentation and it shows great potential and superiority to the existing fermentation methods. (C) 2012 Elsevier B. V. All rights reserved.
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