期刊
JOURNAL OF BIOTECHNOLOGY
卷 152, 期 3, 页码 96-101出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jbiotec.2011.01.023
关键词
Parkinson's disease; MicroRNA; Neurodegenerative disease; RT-qPCR; Molecular marker
资金
- CNPq [485347/2007-5]
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico, Brazil [307213/2008-0, 303967/2008-0]
The present study demonstrates that blood samples can be used as a source of miRNA identification associated to Parkinson's disease (PD). A set of six differentially expressed microRNAs were identified. They form two groups according to their expression profile in control, non-treated, early-onset and treated Parkinson's disease subjects. While miR-1, miR-22* and miR-29 expression levels allowed to distinguish non-treated PD from healthy subjects, miR-16-2*, miR-26a2* and miR30a differentiated treated from untreated patients. This study is innovative in contributing to the development of effective PD biomarkers. (C) 2011 Elsevier B.V. All rights reserved.
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