期刊
JOURNAL OF BIOTECHNOLOGY
卷 140, 期 1-2, 页码 13-17出版社
ELSEVIER
DOI: 10.1016/j.jbiotec.2009.01.007
关键词
Software; Annotation; Antibiotics; Polyketide; Nonribosomal peptide synthesis; NRPSpredictor
资金
- BMBF [0313805J]
Bacterial secondary metabolites are an important Source of antimicrobial and cytostatic drugs. These molecules are often synthesized in a stepwise fashion by multimodular megaenzymes that are encoded in Clusters of genes encoding enzymes for precursor supply and modification. In this work, we present an open Source software pipeline, CLUSEAN (CLUster SEquence ANalyzer) that helps to annotate and analyze such gene clusters. CLUSEAN integrates standard analysis tools, like BLAST and HMMer, with specific tools for the identification of the functional domains and motifs in nonribosomal peptide synthetases (NRPS)/type I polyketide synthases (PKS) and the prediction of specificities of NRPS. (C) 2009 Elsevier B.V. All rights reserved.
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