期刊
JOURNAL OF BIOTECHNOLOGY
卷 142, 期 2, 页码 114-122出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jbiotec.2009.04.007
关键词
Glutamate dehydrogenase; GlxR; Nitrogen control; Nitrogen regulation; Sigma factors; Stringent response
Glutamate dehydrogenase is a central enzyme connecting nitrogen and carbon metabolism via its precursors ammonium and oxoglutarate and its product glutamate. In Corynebacterium glutamicum glutamate dehydrogenase is especially important. since it is a key enzyme for the biotechnological production of the flavour enhancer L-glutamate. In this study, the regulation of gdh transcription was investigated. While originally described as a constitutively expressed gene, we could show that gdh transcription is highly variable depending on environmental conditions. Regulation of the gdh gene by the C. glutamicum nitrogen control protein AmtR was analyzed in detail in this study. (C) 2009 Elsevier B.V. All rights reserved.
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