期刊
NEURAL REGENERATION RESEARCH
卷 10, 期 5, 页码 679-685出版社
WOLTERS KLUWER MEDKNOW PUBLICATIONS
DOI: 10.4103/1673-5374.156943
关键词
living scaffolds; neural tissue engineering; cell transplant; biomaterials; regeneration; neurotrauma; neurodegeneration; axon pathfinding; cell migration
资金
- U.S. Army Medical Research and Materiel Command through the Joint Warfighter Medical Research Program [W81XWH-13-13207004]
- Axonia Medical, Inc.
- Department of Veterans Affairs (RRD Merit Review) [B1097-I]
- National Institutes of Health [NINDS T32-NS043126]
- Penn Medicine Neuroscience Center
- National Science Foundation [DGE-1321851]
Neural tissue engineering is premised on the integration of engineered living tissue with the host nervous system to directly restore lost function or to augment regenerative capacity following nervous system injury or neurodegenerative disease. Disconnection of axon pathways - the long-distance fibers connecting specialized regions of the central nervous system or relaying peripheral signals - is a common feature of many neurological disorders and injury. However, functional axonal regeneration rarely occurs due to extreme distances to targets, absence of directed guidance, and the presence of inhibitory factors in the central nervous system, resulting in devastating effects on cognitive and sensorimotor function. To address this need, we are pursuing multiple strategies using tissue engineered living scaffolds, which are preformed three-dimensional constructs consisting of living neural cells in a defined, often anisotropic architecture. Living scaffolds are designed to restore function by serving as a living labeled pathway for targeted axonal regeneration - mimicking key developmental mechanisms- or by restoring lost neural circuitry via direct replacement of neurons and axonal tracts. We are currently utilizing preformed living scaffolds consisting of neuronal clusters spanned by long axonal tracts as regenerative bridges to facilitate long-distance axonal regeneration and for targeted neurosurgical reconstruction of local circuits in the brain. Although there are formidable challenges in preclinical and clinical advancement, these living tissue engineered constructs represent a promising strategy to facilitate nervous system repair and functional recovery.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据