期刊
NEURAL REGENERATION RESEARCH
卷 10, 期 1, 页码 7-9出版社
WOLTERS KLUWER MEDKNOW PUBLICATIONS
DOI: 10.4103/1673-5374.150637
关键词
hippocampus; adult neurogenesis; physical exercise; voluntary wheel running; depression; neural progenitor cell; adipocyte; adiponectin; adiponectin receptor; AMP-activated protein kinase
资金
- Hong Kong Health and Medical Research Fund
- Leading Talents of Guangdong
- Programme of Introducing Talents of Discipline to Universities [B14036]
- International
- Hong Kong, Macao
- Taiwan Science and Technology Cooperation Innovation Platform in Universities in Guangdong Province, China [2013gjhz0002]
- Jinan University Guangdong-Hong Kong-Macau Cooperation and Innovation Center for Tissue Regeneration and Repair
- State Key Laboratory of Pharmaceutical Biotechnology, Hong Kong SAR, China
Psychological depression is drawing accumulating attention nowadays, due to the skyrocketing incidence worldwide and the enormous burdens it incurs. Physical exercise has been long recognized for its therapeutic effects on depressive disorders, although knowledge of the underlying mechanisms remains limited. Suppressed hippocampal neurogenesis in adult brains has been regarded, at least partly, contributive to depression, whereas physical exercise that restores neurogenesis accordingly exerts the anti-depressive action. Several recent publications have suggested the potential role of adiponectin, a protein hormone secreted by peripheral mature adipocytes, in mediating physical exercise-triggered enhancement of hippocampal neurogenesis and alleviation of depression. Here, we briefly review these novel findings and discuss the possibility of counteracting depression by modulating adiponectin signaling in the hippocampus with interventions including physical exercise and administration of pharmacological agents.
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