期刊
JOURNAL OF BIOSCIENCES
卷 36, 期 5, 页码 921-928出版社
INDIAN ACAD SCIENCES
DOI: 10.1007/s12038-011-9158-2
关键词
Minihelix; peptide bond formation; proto-tRNA; ribosome; RNA dimer
类别
资金
- PRESTO
- Japan Science and Technology Agency (JST), Japan
- Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan
Proteins, the main players in current biological systems, are produced on ribosomes by sequential amide bond (peptide bond) formations between amino-acid-bearing tRNAs. The ribosome is an exquisite super-complex of RNA-proteins, containing more than 50 proteins and at least 3 kinds of RNAs. The combination of a variety of side chains of amino acids (typically 20 kinds with some exceptions) confers proteins with extraordinary structure and functions. The origin of peptide bond formation and the ribosome is crucial to the understanding of life itself. In this article, a possible evolutionary pathway to peptide bond formation machinery (proto-ribosome) will be discussed, with a special focus on the RNA minihelix (primordial form of modern tRNA) as a starting molecule. Combining the present data with recent experimental data, we can infer that the peptidyl transferase center (PTC) evolved from a primitive system in the RNA world comprising tRNA-like molecules formed by duplication of minihelix-like small RNA.
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