期刊
JOURNAL OF BIOSCIENCES
卷 34, 期 4, 页码 503-511出版社
INDIAN ACAD SCIENCES
DOI: 10.1007/s12038-009-0069-4
关键词
Acid resistance; bacterial patrogenesis; structural genomics
类别
The urease of the human pathogen, Helicobacter pylori, is essential for pathogenesis. The ammonia produced by the enzyme neutralizes stomach acid; thereby modifying its environment. The dodecameric enzyme complex has high affinity for its substrate, urea. We compared urease sequences and derivative 3D homology model structures from all published Helicobacter genomes and an equal number of genomes belonging to strains of another enteric bacterium, Escherichia coli. We found that the enzyme's architecture adapts to fit its niche. This finding, coupled to a survey of other physiological features responsible for the bacterium's acid resistance, suggests how it copes with pH changes caused by disease onset and progression.
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