期刊
JOURNAL OF BIOSCIENCE AND BIOENGINEERING
卷 114, 期 1, 页码 92-95出版社
SOC BIOSCIENCE BIOENGINEERING JAPAN
DOI: 10.1016/j.jbiosc.2012.02.011
关键词
Cultured neuronal networks; Microfluidics; Micropatterning; Poly(dimethylsiloxane) (PDMS); Neurite guidance
资金
- Japan Society for the Promotion of Science [22.4785]
- Grants-in-Aid for Scientific Research [10J04785] Funding Source: KAKEN
We present a simple method to regulate the direction of axon development in cultured neurons using microfabrication and microfluidics techniques. We fabricate a PDMS-based device and place it onto a chemically micropatterned glass substrate. We confirm that cultured neurons extend neurites along the medium flow direction and the micropatterned regions. (C) 2012, The Society for Biotechnology, Japan. All rights reserved.
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