期刊
JOURNAL OF BIOPHOTONICS
卷 7, 期 3-4, 页码 232-240出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/jbio.201400010
关键词
Raman spectroscopy; blood plasma; label-free diagnostics; sepsis; SIRS
资金
- BMBF via the Integrated Research and Treatment Center Center for Sepsis Control and Care (CSCC) [FKZ 01EO1002]
Currently, there is no biomarker that can reliable distinguish between infectious and non-infectious systemic inflammatory response syndrome (SIRS). However, such a biomarker would be of utmost importance for early identification and stratification of patients at risk to initiate timely and appropriate antibiotic treatment. Within this proof of principle study, the high potential of Raman spectroscopy for the fast differentiation of non-infectious SIRS and sepsis is demonstrated. Blood plasma collected from 70 patients from the intensive care unit (31 patients with sepsis and 39 patients classified with SIRS without infection) was analyzed by means of Raman spectroscopy. A PCA-LDA based classification model was trained with Raman spectra from test samples and yielded for sepsis a sensitivity of 1.0 and specificity of 0.82. These results have been confirmed with an independent dataset (prediction accuracy 80%). ((c) 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim)
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