期刊
JOURNAL OF BIOPHOTONICS
卷 8, 期 9, 页码 694-704出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/jbio.201400039
关键词
cell membrane extensions; multicellular spheroids; squamous cell carcinoma; optical tweezers
The use of optical trap and microbeam for investigating mechanical and transport properties of inter cellular tunneling nanotubes (TnTs) in tumor spheroids has been demonstrated. TnTs in tumor spheroids have been visualized by manipulating TnT connected cells using optical tweezers. Functionality of the TnTs for transferring cytoplasmic vesicles and injected dye molecules by optoporation method has been studied. Further, the TnTs could be longitudinally stretched by manipulating the connected cells and their elastic response was studied. [GRAPHICS] Manipulation of cells at the surface of tumor spheroid using optical tweezers and injection of fluorescent dye into a trapped cell using optoporation technique.
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