期刊
JOURNAL OF BIOPHOTONICS
卷 7, 期 3-4, 页码 189-199出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/jbio.201300149
关键词
serum; filtrate; glioma; rapid; spectroscopy; infrared; ATR-FTIR; cancer
资金
- Brain Tumour North West
- Sydney Driscoll Neuroscience Foundation
- Centre for Materials Science at the University of Central Lancashire
Gliomas are the most frequent primary brain tumours in adults with over 9,000 people diagnosed each year in the UK. A rapid, reagent-free and cost-effective diagnostic regime using serum spectroscopy would allow for rapid diagnostic results and for swift treatment planning and monitoring within the clinical environment. We report the use of ATR-FTIR spectral data combined with a RBF-SVM for the diagnosis of gliomas (high-grade and low-grade) from non-cancer with sensitivities and specificities on average of 93.75 and 96.53% respectively. The proposed diagnostic regime has the ability to reduce mortality and morbidity rates. ((c) 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim)
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