期刊
JOURNAL OF BIOPHOTONICS
卷 8, 期 4, 页码 317-323出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/jbio.201400104
关键词
circularly polarized light; angular momentum; multiple scattering; cancer detection; Stokes vector; Poincaresphere; tissue samples; optical biopsy
资金
- Health Research Council of New Zealand (HRC)
- Maurice Wilkins Centre (MWC)
- University of Otago
- Faculty of Science, VU University Amsterdam, The Netherlands
- Dutch Cancer Society
Polarization-based optical techniques have become increasingly popular in the field of biomedical diagnosis. In the current report we exploit the directional awareness of circularly and/or elliptically polarized light backscattered from turbid tissue-like scattering media. We apply circularly and elliptically polarized laser light which illuminates the samples of interest, and a standard optical polarimeter is used to observe the polarization state of light backscattered a few millimeters away from the point of incidence. We demonstrate that the Stokes vector of backscattered light depicted on a Poincare sphere can be used to assess a turbid tissue-like scattering medium. By tracking the Stokes vector of the detected light on the Poincare sphere, we investigate the utility of this approach for characterization of cancerous and non-cancerous tissue samples in vitro. The obtained results are discussed in the framework of a phenomenological model and the results of a polarization tracking Monte Carlo model, developed in house.
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