期刊
JOURNAL OF BIOPHOTONICS
卷 7, 期 9, 页码 703-712出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/jbio.201300045
关键词
Monte Carlo simulation; Tissue Raman spectroscopy; Skin optical model; Intrinsic Raman of skin
资金
- Canadian Cancer Society
- Canadian Institutes of Health Research
- Canadian Dermatology Foundation
- Major Research Plan of the Natural Science Foundation of China [91123030]
- International Science & Technology Cooperation Program of China [2011DFA12220]
- Natural Science Fund of Shaanxi Province, China [2010JK868]
- Natural Science Research Foundation of Northwest University, China [12NW11]
Raman photon generation inside human skin and escaping to skin surface were modeled in an eight-layered skin optical model. Intrinsic Raman spectra of different skin layers were determined by microscopy measurements of excised skin tissue sections. Monte Carlo simulation was used to study the excitation light distribution and intrinsic Raman signal distortion caused by tissue reabsorption and scattering during in vivo measurements. The simulation results demonstrated how different skin layers contributed to the observed in vivo Raman spectrum. Using the strongest Raman peak at 1445 cm(-1) as an example, the simulation suggested that the integrated contributions of the stratum corneum layer is 1.3%, the epidermis layer 28%, the dermis layer 70%, and the subcutaneous fat layer 1.1%. Reasonably good matching between the calculated spectrum and the measured in vivo Raman spectra was achieved, thus demonstrated great utility of our modeling method and approaches for help understanding the clinical measurements.
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