期刊
JOURNAL OF BIOPHOTONICS
卷 5, 期 3, 页码 220-229出版社
WILEY-BLACKWELL
DOI: 10.1002/jbio.201100098
关键词
Raman spectroscopy; image reconstruction; computer assisted diagnosis; microscopy
资金
- Department of Health [II-AR-0209-10012, FSG004] Funding Source: Medline
- National Institute for Health Research [FSG004, II-AR-0209-10012] Funding Source: researchfish
- National Institutes of Health Research (NIHR) [FSG004, II-AR-0209-10012] Funding Source: National Institutes of Health Research (NIHR)
A method is presented for acquiring high-spatial-resolution spectral maps, in particular for Raman micro-spectroscopy (RMS), by selectively sampling the spatial features of interest and interpolating the results. This method achieves up to 30 times reduction in the sampling time compared to raster-scanning, the resulting images have excellent correlation with conventional histopathological staining, and are achieved with sufficient spectral signal-to-noise ratio to identify individual tissue structures. The benefits of this selective sampling method are not limited to tissue imaging however; it is expected that the method may be applied to other techniques which employ point-by-point mapping of large substrates. (C) 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim)
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