期刊
JOURNAL OF BIOPHOTONICS
卷 3, 期 5-6, 页码 385-407出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/jbio.200900087
关键词
medical imaging; optical scanning; endoscopy; endomicroscopy; two-photon microscopy
资金
- NIBIB [R01008119, RC1EB010900]
- NCI [U54 CA136429, CA128231]
- W. H. Coulter Foundation
- Whitaker Foundation
- Washington Technology Center
- NSF [CBET 0809070]
- NIH/NCI [R21 CA110184, R21/R33 CA094303]
- PENTAX (HOYA Corporation)
- Human Frontier Science Program
- Swiss National Center
- EU [200873]
In modern endoscopy, wide field of view and full color are considered necessary for navigating inside the body, inspecting tissue for disease and guiding interventions such as biopsy or surgery. Current flexible endoscope technologies suffer from reduced resolution when device diameter shrinks. Endoscopic procedures today, using coherent fiber-bundle technology on the scale of 1 mm, are performed with such poor image quality that the clinician's vision meets the criteria for legal blindness. Here, we review a new and versatile scanning fiber-imaging technology and describe its implementation for ultrathin and flexible endoscopy. This scanning fiber endoscope (SPE) or catheterscope enables high-quality, laser-based, video imaging for ultrathin clinical applications, while also providing new options for in vivo biological research of subsurface tissue and high resolution fluorescence imaging. [GRAPHICS] Looking into the imaging head of a 1.2 mm scanning fiber endoscope
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