期刊
JOURNAL OF BIOPHOTONICS
卷 2, 期 6-7, 页码 389-397出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/jbio.200910013
关键词
OCT; multiphoton tomography; skin; SHG; molecular imaging; two-photon; skin cancer; optical biopsy
资金
- European Commission [HEALTHF5-2008-201880]
- JenLab GmbH
We report on the first clinical study based on optical coherence tomography (OCT) in combination with multiphoton tomography (MPT) and dermoscopy. 47 patients with a variety of skin diseases and disorders such as skin cancer, psoriasis, hemangioma, connective tissue diseases, pigmented lesions, and autoimmune bullous skin diseases have been investigated with (i) state-of-the-art OCT systems for dermatology including multibeam swept source OCT, (H) the femtosecond laser multiphoton tomograph, and (iii) dermoscopes. Dermoscopy provides two-dimensional color images of the skin surface. OCT images reflect modifications of the intratissue refractive index whereas MPT is based on nonlinear excitation of endogenous fluorophores and second harmonic generation. A stack of cross-sectional OCT wide field images with a typical field of view of 5 x 2 mm(2) gave fast. information on the depth and the volume of the lesion. Multiphoton tomography provided 036 x 0.36 mm(2) horizontal/diagonal optical sections within seconds of a particular region. of interest with superior submicron resolution down to a [GRAPHICS] Scheme of the multi-beam OCT tissue depth of. 200 mu m. The combination of OCT and MPT provides a unique powerful optical imaging modality for early detection of skin cancer and other skin diseases, as well as for the evaluation of the efficiency of treatments. (C) 2009 by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
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