期刊
JOURNAL OF BIOPHOTONICS
卷 3, 期 1-2, 页码 25-33出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/jbio.200910075
关键词
optical coherence tomography; permeability rate; diffusion; skin
资金
- NIH [R01 HL095586]
- Office of Naval Research [N000140710943]
- NEI [1 RO1 EY014651]
- CRDF [RUB1-2932-SR-08]
- Federal Agency of Education of RF [2.1.1/4989, 2.2.1.1/2950, 1.4.09]
- RF [208.2008.2, 224014]
- NATIONAL EYE INSTITUTE [R01EY014651] Funding Source: NIH RePORTER
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL095586] Funding Source: NIH RePORTER
Topical trans-dermal delivery of drugs has proven to be a promising route for treatment of many dermatological diseases. The aim of this study is to monitor and quantify the permeability rate of glucose solutions in rhesus monkey skin noninvasively in vivo as a primate model for drug diffusion. A time-domain Optical Coherence Tomography (OCT) system was used to image the diffusion of glucose in the skin of anesthetized monkeys for which the permeability rate was calculated. From 5 experiments on 4 different monkeys, the permeability for glucose-20% was found to be (4.41 +/- 0.28) 10(-6) cm/sec. The results suggest that OCT might be utilized for the noninvasive study of molecular diffusion in the multilayered biological tissues in vivo. [GRAPHICS] 3D representation of glucose diffusion in monkey skin (C) 2010 by WILEY-VCH Verlag GmbH & Co. KGaA. Weinheim
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