期刊
ANTIVIRAL RESEARCH
卷 120, 期 -, 页码 122-125出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.antiviral.2015.06.001
关键词
Porcine reproductive and respiratory syndrome virus (PRRSV); Glycyrrhizin; Proliferation; Penetration
资金
- National Natural Sciences Foundation of China [31490602, 31201890, 31328023]
- National Key Basic Research Program of China (973 Program) [2014CB542703]
- Keygrant Project of Chinese Ministry of Education [313025]
Glycyrrhizin is a natural component extracted from the roots of Glycyrrhiza glabra. In this study, we investigated the antiviral activity of glycyrrhizin against porcine reproductive and respiratory syndrome virus (PRRSV), an Arterivirus that has been devastating the swine industry worldwide since the late 1980s. Our results showed that treatment with glycyrrhizin significantly reduced PRRSV proliferation and PRRSV-encoded protein expression in a dose-dependent manner. Mechanistically, glycyrrhizin mainly inhibits the penetration stage, and has little effect on the steps of adsorption or release of PRRSV in its life cycle. Furthermore, we were able to exclude a direct inhibitory action of glycyrrhizin on PRRSV particles. Given these results, glycyrrhizin may be a candidate component for a novel porcine reproductive and respiratory syndrome (PRRS) control strategy. (C) 2015 Elsevier B.V. All rights reserved.
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