期刊
JOURNAL OF BIOPHARMACEUTICAL STATISTICS
卷 18, 期 6, 页码 1184-1196出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/10543400802369053
关键词
Adaptive design; Brownian motion; Conditional power; Markov process; Sample size re-estimation; Sequential design; Transition function
There is considerable interest in methods that use accumulated data to modify trial sample size. However, sample size re-estimation in group sequential designs has been controversial. We describe a method for sample size re-estimation at the penultimate stage of a group sequential design that achieves specified power against an alternative hypothesis corresponding to the current point estimate of the treatment effect.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据