期刊
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
卷 27, 期 2, 页码 111-114出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/07391102.2009.10507301
关键词
Cysteine; Biosynthetic pathway; Methanogenic Archaea; Thermophilic adaptation
资金
- National Key Project for Basic Research [2003CB114400]
- National High Technology Research and Development Program [2008AA09Z411]
- National Natural Science Foundation of China [30870520]
Although cysteine (Cys) is beneficial to stabilize protein structures, it is not prevalent in thermophiles. For instance, the Cys contents in most thermophilic archaea are only around 0.7%. However, methanogenic archaea, no matter thermophilic or not, contain relatively abundant Cys, which remains elusive for a long time. Recently, Klipcan et al. correlated this intriguing property of methanogenic archaea with their unique tRNA-dependent Cys biosynthetic pathway. But, the deep reasons underlying the correlation are ambiguous. Considering the facts that free Cys is thermally labile and the tRNA-dependent Cys biosynthesis avoids the use of free Cys, we speculate that the unique Cys biosynthetic pathway represents a strategy to increase Cys contents by preventing it from thermal degradation, which may be relevant to the thermal adaptation of methanogenic archaeza ancestor.
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