4.1 Review

Controlling Self-Renewal and Differentiation of StemCells via Mechanical Cues

期刊

出版社

HINDAWI LTD
DOI: 10.1155/2012/797410

关键词

-

资金

  1. Politecnico di Milano [5x1000-2009-CUPD41J10000490001]
  2. Biosensors and Artificial Bio-systems (Italian Institute of Technology-iiT, Genova)
  3. Cariplo 3D Micro structuring and Functionalisation of Polymeric Materials for Scaffolds in Regenerative Medicine (Cariplo Foundation, Milano)

向作者/读者索取更多资源

The control of stem cell response in vitro, including self-renewal and lineage commitment, has been proved to be directed by mechanical cues, even in the absence of biochemical stimuli. Through integrin-mediated focal adhesions, cells are able to anchor onto the underlying substrate, sense the surrounding microenvironment, and react to its properties. Substrate-cell and cell-cell interactions activate specific mechanotransduction pathways that regulate stem cell fate. Mechanical factors, including substrate stiffness, surface nanotopography, microgeometry, and extracellular forces can all have significant influence on regulating stem cell activities. In this paper, we review all the most recent literature on the effect of purely mechanical cues on stem cell response, and we introduce the concept of force isotropy relevant to cytoskeletal forces and relevant to extracellular loads acting on cells, to provide an interpretation of how the effects of insoluble biophysical signals can be used to direct stem cells fate in vitro.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.1
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据