相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。Evaluating Factors That Influence Microbial Synthesis Yields by Linear Regression with Numerical and Ordinal Variables
Peter F. Colletti et al.
BIOTECHNOLOGY AND BIOENGINEERING (2011)
Metabolomic Characterization of the Salt Stress Response in Streptomyces coelicolor
Stefan Kol et al.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2010)
Dynamic Flux Responses in Riboflavin Overproducing Bacillus subtilis to Increasing Glucose Limitation in Fed-Batch Culture
Martin Ruehl et al.
BIOTECHNOLOGY AND BIOENGINEERING (2010)
Enhancement of Farnesyl Diphosphate Pool as Direct Precursor of Sesquiterpenes Through Metabolic Engineering of the Mevalonate Pathway in Saccharomyces cerevisiae
Mohammad A. Asadollahi et al.
BIOTECHNOLOGY AND BIOENGINEERING (2010)
Systems metabolic engineering: Genome-scale models and beyond
John Blazeck et al.
BIOTECHNOLOGY JOURNAL (2010)
From fluxes and isotope labeling patterns towards in silico cells
Michael Dauner
CURRENT OPINION IN BIOTECHNOLOGY (2010)
Systems biology of microbial metabolism
Matthias Heinemann et al.
CURRENT OPINION IN MICROBIOLOGY (2010)
Metabolic Fluxes during Strong Carbon Catabolite Repression by Malate in Bacillus subtilis
Roelco J. Kleijn et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
FIVE HARD TRUTHS FOR SYNTHETIC BIOLOGY
Roberta Kwok
NATURE (2010)
Improved computational performance of MFA using elementary metabolite units and flux coupling
Patrick F. Suthers et al.
METABOLIC ENGINEERING (2010)
Application of dynamic flux balance analysis to an industrial Escherichia coli fermentation
Adam L. Meadows et al.
METABOLIC ENGINEERING (2010)
Metabolic flux analysis and pharmaceutical production
Brett A. Boghigian et al.
METABOLIC ENGINEERING (2010)
Model-driven evaluation of the production potential for growth-coupled products of Escherichia coli
Adam M. Feist et al.
METABOLIC ENGINEERING (2010)
Alternative isoleucine synthesis pathway in cyanobacterial species
Bing Wu et al.
MICROBIOLOGY-SGM (2010)
Overproduction of Geranylgeraniol by Metabolically Engineered Saccharomyces cerevisiae
Kenro Tokuhiro et al.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2009)
Characterization of the Central Metabolic Pathways in Thermoanaerobacter sp Strain X514 via Isotopomer-Assisted Metabolite Analysis
Xueyang Feng et al.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2009)
Elementary mode analysis: a useful metabolic pathway analysis tool for characterizing cellular metabolism
Cong T. Trinh et al.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2009)
WEbcoli: an interactive and asynchronous web application for in silico design and analysis of genome-scale E.coli model
Tae-Sung Jung et al.
BIOINFORMATICS (2009)
Overproduction of human interleukin-2 in recombinant Escherichia coli BL21 high-cell-density culture by the determination and optimization of essential amino acids using a simple stoichiometric model
S. Yegane-Sarkandy et al.
BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY (2009)
Systematic Development of Hybrid Cybernetic Models: Application to Recombinant Yeast Co-Consuming Glucose and Xylose
Hyun-Seob Song et al.
BIOTECHNOLOGY AND BIOENGINEERING (2009)
Analysis of Metabolic Pathways and Fluxes in a Newly Discovered Thermophilic and Ethanol-Tolerant Geobacillus Strain
Yinjie J. Tang et al.
BIOTECHNOLOGY AND BIOENGINEERING (2009)
Metabolic engineering ofClostridium acetobutylicumM5 for highly selective butanol production
Jin Young Lee et al.
Biotechnology Journal (2009)
Invariability of Central Metabolic Flux Distribution in Shewanella oneidensis MR-1 Under Environmental or Genetic Perturbations
Yinjie J. Tang et al.
BIOTECHNOLOGY PROGRESS (2009)
In silico approaches to study mass and energy flows in microbial consortia: a syntrophic case study
Reed Taffs et al.
BMC SYSTEMS BIOLOGY (2009)
Flux balance analysis of primary metabolism in Chlamydomonas reinhardtii
Nanette R. Boyle et al.
BMC SYSTEMS BIOLOGY (2009)
Novel biological insights through metabolomics and C-13-flux analysis
Nicola Zamboni et al.
CURRENT OPINION IN MICROBIOLOGY (2009)
Metabolic flux analysis of the hydrogen production potential in Synechocystis sp PCC6803
E. Navarro et al.
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY (2009)
Production of 2-phenylethanol from L-phenylalanine by a stress tolerant Saccharomyces cerevisiae strain
N. Eshkol et al.
JOURNAL OF APPLIED MICROBIOLOGY (2009)
Genome-scale gene/reaction essentiality and synthetic lethality analysis
Patrick F. Suthers et al.
MOLECULAR SYSTEMS BIOLOGY (2009)
ADVANCES IN ANALYSIS OF MICROBIAL METABOLIC FLUXES VIA C-13 ISOTOPIC LABELING
Yinjie J. Tang et al.
MASS SPECTROMETRY REVIEWS (2009)
Direct photosynthetic recycling of carbon dioxide to isobutyraldehyde
Shota Atsumi et al.
NATURE BIOTECHNOLOGY (2009)
Synthetic protein scaffolds provide modular control over metabolic flux
John E. Dueber et al.
NATURE BIOTECHNOLOGY (2009)
C-13-based metabolic flux analysis
Nicola Zamboni et al.
NATURE PROTOCOLS (2009)
Engineering for biofuels: exploiting innate microbial capacity or importing biosynthetic potential?
Hal Alper et al.
NATURE REVIEWS MICROBIOLOGY (2009)
A dynamic, genome-scale flux model of Lactococcus lactis to increase specific recombinant protein expression
Gian M. Oddone et al.
METABOLIC ENGINEERING (2009)
Enhancing sesquiterpene production in Saccharomyces cerevisiae through in silico driven metabolic engineering
Mohammad A. Asadollahi et al.
METABOLIC ENGINEERING (2009)
OpenFLUX: efficient modelling software for 13C-based metabolic flux analysis
Lake-Ee Quek et al.
MICROBIAL CELL FACTORIES (2009)
Linking high-resolution metabolic flux phenotypes and transcriptional regulation in yeast modulated by the global regulator Gcn4p
Joel F. Moxley et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
A Genome-Scale Metabolic Reconstruction of Mycoplasma genitalium, iPS189
Patrick F. Suthers et al.
PLOS COMPUTATIONAL BIOLOGY (2009)
GrowMatch: An Automated Method for Reconciling In Silico/In Vivo Growth Predictions
Vinay Satish Kumar et al.
PLOS COMPUTATIONAL BIOLOGY (2009)
Integration of metabolic modeling and phenotypic data in evaluation and improvement of ethanol production using respiration-deficient mutants of Saccharomyces cerevisiae
Duygu Dikicioglu et al.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2008)
Directed Evolution of Methanococcus jannaschii Citramalate Synthase for Biosynthesis of 1-Propanol and 1-Butanol by Escherichia coli
Shota Atsumi et al.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2008)
Global Transcription and Metabolic Flux Analysis of Escherichia coli in Glucose-Limited Fed-Batch Cultivations
K. Lemuth et al.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2008)
An Elementary Metabolite Unit (EMU) based method of isotopically nonstationary flux analysis
Jarney D. Young et al.
BIOTECHNOLOGY AND BIOENGINEERING (2008)
Metabolic flux analysis in Escherichia coli by integrating isotopic dynamic and isotopic stationary 13C labeling data
Jochen Schaub et al.
BIOTECHNOLOGY AND BIOENGINEERING (2008)
Metabolic flux analysis in biotechnology processes
Shintaro Iwatani et al.
BIOTECHNOLOGY LETTERS (2008)
13C labeling experiments at metabolic nonstationary conditions:: An exploratory study
Sebastian Aljoscha Wahl et al.
BMC BIOINFORMATICS (2008)
Importance of systems biology in engineering microbes for biofuel production
Aindrila Mukhopadhyay et al.
CURRENT OPINION IN BIOTECHNOLOGY (2008)
Towards systems metabolic engineering of microorganisms for amino acid production
Jin Hwan Park et al.
CURRENT OPINION IN BIOTECHNOLOGY (2008)
CcpN controls central carbon fluxes in Bacillus subtilis
Simon Taennler et al.
JOURNAL OF BACTERIOLOGY (2008)
Differential transcriptional analysis of the cyanobacterium Cyanothece sp strain ATCC 51142 during light-dark and continuous-light growth
Joerg Toepel et al.
JOURNAL OF BACTERIOLOGY (2008)
Cyclic AMP-dependent catabolite repression is the dominant control mechanism of metabolic fluxes under glucose limitation in Escherichia coli
Annik Nanchen et al.
JOURNAL OF BACTERIOLOGY (2008)
Elucidation of an alternate isoleucine biosynthesis pathway in Geobacter sulfurreducens
Carla Risso et al.
JOURNAL OF BACTERIOLOGY (2008)
Non-fermentative pathways for synthesis of branched-chain higher alcohols as biofuels
Shota Atsumi et al.
NATURE (2008)
Absolute quantitation of intracellular metabolite concentrations by an isotope ratio-based approach
Bryson D. Bennett et al.
NATURE PROTOCOLS (2008)
Kinetic flux profiling for quantitation of cellular metabolic fluxes
Jie Yuan et al.
NATURE PROTOCOLS (2008)
C-13-metabolic flux analysis of Actinobacillus succinogenes fermentative metabolism at different NaHCO3 and H-2 concentrations
James B. McKinlay et al.
METABOLIC ENGINEERING (2008)
Maintenance metabolism and carbon fluxes in Bacillus species
Simon Taennler et al.
MICROBIAL CELL FACTORIES (2008)
Genome-scale reconstruction of metabolic network in Bacillus subtilis based on high-throughput phenotyping and gene essentiality data
You-Kwan Oh et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Metabolic engineering of Saccharomyces cerevisiae for conversion of D-glucose to xylitol and other five-carbon sugars and sugar alcohols
Mervi H. Tolvari et al.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2007)
Testosterone 15β-hydroxylation by solvent tolerant Pseudomonas putida S12
Harald J. Ruijssenaars et al.
JOURNAL OF BIOTECHNOLOGY (2007)
A transient isotopic labeling methodology for 13C metabolic flux analysis of photo auto trophic microorganisms
Avantika A. Shastri et al.
PHYTOCHEMISTRY (2007)
Genome-scale analysis of Saccharomyces cerevisiae metabolism and ethanol production in fed-batch culture
Jared L. Hjersted et al.
BIOTECHNOLOGY AND BIOENGINEERING (2007)
High-level production of beta-carotene in Saccharomyces cerevisiae by successive transformation with carotenogenic genes from Xanthophyllomyces dendrorhous
Rene Verwaal et al.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2007)
Systematic evaluation of objective functions for predicting intracellular fluxes in Escherichia coli
Robert Schuetz et al.
MOLECULAR SYSTEMS BIOLOGY (2007)
Metabolic characterization of Escherichia coli strains adapted to growth on lactate
Qiang Hua et al.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2007)
Study on roles of anaplerotic pathways in glutamate overproduction of Corynebacterium glutamicum by metabolic flux analysis
Tomokazu Shirai et al.
MICROBIAL CELL FACTORIES (2007)
Flux analysis of central metabolic pathways in Geobacter metallireducens during reduction of soluble Fe(III)-nitrilotriacetic acid
Yinjie J. Tang et al.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2007)
Metabolic flux analysis in a nonstationary system:: Fed-batch fermentation of a high yielding strain of E. coli producing 1,3-propanediol
Maciek R. Antoniewicz et al.
METABOLIC ENGINEERING (2007)
Metabolic flux analysis at ultra short time scale:: Isotopically non-stationary 13C labeling experiments
Katharina Noeh et al.
JOURNAL OF BIOTECHNOLOGY (2007)
Multiple high-throughput analyses monitor the response of E-coli to perturbations
Nobuyoshi Ishii et al.
SCIENCE (2007)
Quantifying the metabolic capabilities of engineered Zymomonas mobilis using linear programming analysis
Ivi C. Tsantili et al.
MICROBIAL CELL FACTORIES (2007)
Production of p-hydroxycinnamic acid from glucose in Saccharomyces cerevisiae and Escherichia coli by expression of heterologous genes from plants and fungi
Todd Vannelli et al.
METABOLIC ENGINEERING (2007)
Metabolic flux analysis of a glycerol-overproducing Saccharomyces cerevisiae strain based on GC-MS, LC-MS and NMR-derived 13C-labelling data
Roelco J. Kleijn et al.
FEMS YEAST RESEARCH (2007)
Engineering of the pyruvate dehydrogenase bypass in Saccharomyces cerevisiae for high-level production of isoprenoids
Yoichiro Shiba et al.
METABOLIC ENGINEERING (2007)
Determining Actinobacillus succinogenes metabolic pathways and fluxes by NMR and GC-MS analyses of 13C-labeled metabolic product isotopomers
James B. McKinlay et al.
METABOLIC ENGINEERING (2007)
Determination of metabolic flux changes during fed-batch cultivation from measurements of intracellular amino acids by LC-MS/MS
Shintaro Iwatani et al.
JOURNAL OF BIOTECHNOLOGY (2007)
Quantitative prediction of cellular metabolism with constraint-based models: the COBRA Toolbox
Scott A. Becker et al.
NATURE PROTOCOLS (2007)
Elementary metabolite units (EMU): A novel framework for modeling isotopic distributions
Maciek R. Antoniewicz et al.
METABOLIC ENGINEERING (2007)
A kinetic model describing Shewanella oneidensis MR-1 growth, substrate consumption, and product secretion
Yinjie J. Tang et al.
BIOTECHNOLOGY AND BIOENGINEERING (2007)
Metabolic flux elucidation for large-scale models using C-13 labeled isotopes
Patrick F. Suthers et al.
METABOLIC ENGINEERING (2007)
Engineering yeast transcription machinery for improved ethanol tolerance and production
Hal Alper et al.
SCIENCE (2006)
Genome-scale in silico aided metabolic analysis and flux comparisons of Escherichia coli to improve succinate production
Qingzhao Wang et al.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2006)
Computational tools for isotopically instationary 13C labeling experiments under metabolic steady state conditions
Katharina Noeh et al.
METABOLIC ENGINEERING (2006)
Multiple knockout analysis of genetic robustness in the yeast metabolic network
David Deutscher et al.
NATURE GENETICS (2006)
Effects of recombinant precursor pathway variations on poly [(R)-3-hydroxybutyrate] synthesis in Saccharomyces cerevisiae
Ross Carlson et al.
JOURNAL OF BIOTECHNOLOGY (2006)
13C-labeled gluconate tracing as a direct and accurate method for determining the pentose phosphate pathway split ratio in Penicillium chrysogenum
Roelco J. Kleijn et al.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2006)
Designed divergent evolution of enzyme function
Y Yoshikuni et al.
NATURE (2006)
Production of the antimalarial drug precursor artemisinic acid in engineered yeast
DK Ro et al.
NATURE (2006)
Latent pathway activation and increased pathway capacity enable Escherichia coli adaptation to loss of key metabolic enzymes
SS Fong et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
In silico aided metabolic engineering of Saccharomyces cerevisiae for improved bioethanol production
C Bro et al.
METABOLIC ENGINEERING (2006)
Accumulation of homolanthionine and activation of a novel pathway for isoleucine biosynthesis in Corynebacterium glutamicum McbR deletion strains
JO Kromer et al.
JOURNAL OF BACTERIOLOGY (2006)
Metabolic engineering of Escherichia coli for enhanced production of succinic acid, based on genome comparison and in silico gene knockout simulation
SJ Lee et al.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2005)
Characterization of the metabolic shift between oxidative and fermentative growth in Saccharomyces cerevisiae by comparative 13C flux analysis -: art. no. 30
O Frick et al.
MICROBIAL CELL FACTORIES (2005)
Flux balance analysis of photoautotrophic metabolism
AA Shastri et al.
BIOTECHNOLOGY PROGRESS (2005)
In silico design and adaptive evolution of Escherichia coli for production of lactic acid
SS Fong et al.
BIOTECHNOLOGY AND BIOENGINEERING (2005)
Comparative metabolic network analysis of two xylose fermenting recombinant Saccharomyces cerevisiae strains
T Grotkjær et al.
METABOLIC ENGINEERING (2005)
Metabolic engineering of the phenylpropanoid pathway in Saccharomyces cerevisiae
HX Jiang et al.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2005)
Large-scale in vivo flux analysis shows rigidity and suboptimal performance of Bacillus subtilis metabolism
E Fischer et al.
NATURE GENETICS (2005)
Identifying gene targets for the metabolic engineering of lycopene biosynthesis in Escherichia coli
H Alper et al.
METABOLIC ENGINEERING (2005)
Metabolic-flux analysis of Saccharomyces cerevisiae CEN.PK113-7D based on mass isotopomer measurements of 13C-labeled primary metabolites
WA van Winden et al.
FEMS YEAST RESEARCH (2005)
Metabolic-flux and network analysis in fourteen hemiascomycetous yeasts
LM Blank et al.
FEMS YEAST RESEARCH (2005)
Transient expression and flux changes during a shift from high to low riboflavin production in continuous cultures of Bacillus subtilis
N Zamboni et al.
BIOTECHNOLOGY AND BIOENGINEERING (2005)
Large-scale C-13-flux analysis reveals mechanistic principles of metabolic network robustness to null mutations in yeast
LM Blank et al.
GENOME BIOLOGY (2005)
Molecular basis for anaerobic growth of Saccharomyces cerevisiae on xylose, investigated by global gene expression and metabolic flux analysis
M Sonderegger et al.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2004)
Robustness of cellular functions
J Stelling et al.
CELL (2004)
Enzyme-to-enzyme channelling in the early steps of glycolysis in rat pancreatic islets
WJ Malaisse et al.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2004)
Metabolic network analysis of the causes and evolution of enzyme dispensability in yeast
B Papp et al.
NATURE (2004)
Directed evolution of pyruvate decarboxylase-negative Saccharomyces cerevisiae, yielding a C-2-independent, glucose-tolerant, and pyruvate-hyperproducing yeast
AJA van Maris et al.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2004)
Production of L-ascorbic acid by metabolically engineered Saccharomyces cerevisiae and Zygosaccharomyces bailii
M Sauer et al.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2004)
OptKnock: A bilevel programming framework for identifying gene knockout strategies for microbial strain optimization
AP Burgard et al.
BIOTECHNOLOGY AND BIOENGINEERING (2003)
Total biosynthesis of hydrocortisone from a simple carbon source in yeast
FM Szczebara et al.
NATURE BIOTECHNOLOGY (2003)
Unveiling steady-state multiplicity in hybridoma cultures: The cybernetic approach
AA Namjoshi et al.
BIOTECHNOLOGY AND BIOENGINEERING (2003)
Dynamic flux balance analysis of diauxic growth in Escherichia coli
R Mahadevan et al.
BIOPHYSICAL JOURNAL (2002)
Metabolic flux analysis in Synechocystis using isotope distribution from 13C-labeled glucose
C Yang et al.
METABOLIC ENGINEERING (2002)
Metabolic engineering of glycerol production in Saccharomyces cerevisiae
KM Overkamp et al.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2002)
Isolating uncultivable microorganisms in pure culture in a simulated natural environment
T Kaeberlein et al.
SCIENCE (2002)
Metabolic engineering of lactic acid bacteria, the combined approach: kinetic modelling, metabolic control and experimental analysis
MHN Hoefnagel et al.
MICROBIOLOGY-SGM (2002)