期刊
JOURNAL OF BIOMEDICAL OPTICS
卷 19, 期 1, 页码 -出版社
SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS
DOI: 10.1117/1.JBO.19.1.016005
关键词
activatable photoacoustic imaging; ultrasound imaging; microbubbles; methylene blue; dual-modality contrast agent
资金
- Samsung Medison
- NRF grant of Korea government [Ministry of Science, ICT and Future Planning (MSIP)] [2011-0030075]
- MSIP, Korea, under the IT Consilience Creative Program [NIPA-2013-H0203-13-1001]
Ultrasound and photoacoustic imaging are highly complementary modalities since both use ultrasonic detection for operation. Increasingly, photoacoustic and ultrasound have been integrated in terms of hardware instrumentation. To generate a broadly accessible dual-modality contrast agent, we generated microbubbles (a standard ultrasound contrast agent) in a solution of methylene blue (a standard photoacoustic dye). This MB2 solution was formed effectively and was optimized as a dual-modality contrast solution. As microbubble concentration increased (with methylene blue concentration constant), photoacoustic signal was attenuated in the MB2 solution. When methylene blue concentration increased (with microbubble concentration held constant), no ultrasonic interference was observed. Using an MB2 solution that strongly attenuated all photoacoustic signal, high powered ultrasound could be used to burst the microbubbles and dramatically enhance photoacoustic contrast (>800-fold increase), providing a new method for spatiotemporal control of photoacoustic signal generation. (C) 2014 Society of Photo-Optical Instrumentation Engineers (SPIE)
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