期刊
JOURNAL OF BIOMEDICAL OPTICS
卷 18, 期 5, 页码 -出版社
SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS
DOI: 10.1117/1.JBO.18.5.056007
关键词
optical coherence tomography; adaptive optics; mouse retina
资金
- CIHR-Canadian Institutes of Health Research
- NSERC-Natural Sciences and Engineering Research Council of Canada
- MSFHR-Michael Smith Foundation for Health Research
- FFB-Foundation Fighting Blindness
- National Eye Institute [EY 014743]
- UC Davis RISE Grant
- Research to Prevent Blindness
- Iris AO
- Directorate For Engineering
- Div Of Industrial Innovation & Partnersh [1068109] Funding Source: National Science Foundation
- Div Of Industrial Innovation & Partnersh
- Directorate For Engineering [1068070] Funding Source: National Science Foundation
Small animal models of retinal diseases are important to vision research, and noninvasive high resolution in vivo rodent retinal imaging is becoming an increasingly important tool used in this field. We present a custom Fourier domain optical coherence tomography (FD-OCT) instrument for high resolution imaging of mouse retina. In order to overcome aberrations in the mouse eye, we incorporated a commercial adaptive optics system into the sample arm of the refractive FD-OCT system. Additionally, a commercially available refraction canceling lens was used to reduce lower order aberrations and specular back-reflection from the cornea. Performance of the adaptive optics (AO) system for correcting residual wavefront aberration in the mice eyes is presented. Results of AO FD-OCT images of mouse retina acquired in vivo with and without AO correction are shown as well. (C) The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI. [DOI: 10.1117/1.JBO.18.5.056007]
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