期刊
JOURNAL OF BIOMEDICAL OPTICS
卷 16, 期 1, 页码 -出版社
SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS
DOI: 10.1117/1.3528646
关键词
tissue phantoms; Monte Carlo; fluorescence; contrast; optimization
资金
- Canadian Institutes of Health Research (CIHR) [RMF-72551]
- Natural Sciences and Engineering Research Council of Canada
The use of phantoms comprising diluted tissue homogenates with a buried capillary containing quantum dots is demonstrated as a method to investigate the optical and biophysical factors influencing the imaging of subsurface fluorescence contrast agents. Validation of the method is demonstrated using both liquid phantoms of known optical absorption and reduced scattering and Monte Carlo computer simulations of photon transport. Conclusions regarding the optimal excitation wavelength are given and quantified with respect to the tissue optical properties. The tissue homogenate method should be of value for quantitative optimization studies relevant to, for example, endoscopic imaging. (C) 2011 Society of Photo-Optical Instrumentation Engineers (SHE). [DOI: 10.1117/1.3528646]
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