期刊
JOURNAL OF BIOMEDICAL OPTICS
卷 16, 期 5, 页码 -出版社
SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS
DOI: 10.1117/1.3581111
关键词
optical property; tumor tissue; photodynamic therapy; inverse Monte Carlo technique; double integrating sphere
资金
- SENTAN, JST
- Grants-in-Aid for Scientific Research [22700471] Funding Source: KAKEN
Photodynamic therapy (PDT) efficacy depends on the amount of light distribution within the tissue. However, conventional PDT does not consider the laser irradiation dose during PDT. The optical properties of biological tissues (absorption coefficient mu(a), reduced scattering coefficient mu'(s), anisotropy factor g, refractive index, etc.) help us to recognize light propagation through the tissue. The goal of this paper is to acquire the knowledge of the light propagation within tissue during and after PDT with the optical property of PDT-performed mouse tumor tissue. The optical properties of mouse tumor tissues were evaluated using a double integrating sphere setup and the algorithm based on the inverse Monte Carlo method in the wavelength range from 350 to 1000 nm. During PDT, the mu(a) and mu'(s) were not changed after 1 and 5 min of irradiation. After PDT, the mu'(s) in the wavelength range from 600 to 1000 nm increased with the passage of time. For seven days after PDT, the mu'(s) increased by 1.7 to 2.0 times, which results in the optical penetration depth decreased by 1.4 to 1.8 times. To ensure an effective procedure, the adjustment of laser parameters for the decreasing penetration depth is recommended for the re-irradiation of PDT. (C) 2011 Society of Photo-Optical Instrumentation Engineers (SPIE). [DOI: 10.1117/1.3581111]
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