期刊
ANTIVIRAL RESEARCH
卷 113, 期 -, 页码 33-48出版社
ELSEVIER
DOI: 10.1016/j.antiviral.2014.10.014
关键词
Microbicides; HIV; Nanotechnology; Nanomedicine
资金
- Fondo de Investigacion Sanitaria (FIS) [PI13/02016]
- Red Espanola de Investigacion en SIDA (RIS) [RD12-0017-0037, PT13/0010/0028, RD12/0017/0029]
- CYTED [214RT0482]
- Fundacion para la Investigacion y la Prevencion del Sida en Espana (FIPSE)
- Comunidad de Madrid [S-2010/BMD-2351, S-2010/BMD-2332]
- MEC [CTQ2011-23245]
- VI National RDi Plan
- Iniciativa Ingenio
- Consolider Program
- CIBER Actions
- Instituto de Salud Carlos III
More than three decades since its discovery, HIV infection remains one of the most aggressive epidemics worldwide, with more than 35 million people infected. In sub-Saharan Africa, heterosexual transmissions represent nearly 80% of new infections, with 50% of these occurring in women. In an effort to stop the dramatic spread of the HIV epidemic, new preventive treatments, such as microbicides, have been developed. Nanotechnology has revolutionized this field by designing and engineering novel highly effective nano-sized materials as microbicide candidates. This review illustrates the most recent advances in nano-tech-derived HIV prevention strategies, as well as the main steps required to translate promising in vitro results into clinical trials. (C) 2014 Elsevier B.V. All rights reserved.
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