期刊
JOURNAL OF BIOMEDICAL OPTICS
卷 15, 期 1, 页码 -出版社
SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS
DOI: 10.1117/1.3327279
关键词
fluorescence lifetime spectroscopy; fluorescence lifetime imaging microscopy (FLIM); atherosclerotic plaques; intravascular ultrasound
资金
- National Institute of Health [R01 HL 67377]
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL067377] Funding Source: NIH RePORTER
We review fluorescence lifetime techniques including timeresolved laser-induced fluorescence spectroscopy (TR-LIFS) and fluorescence lifetime imaging microscopy (FLIM) instrumentation and associated methodologies that allow for characterization and diagnosis of atherosclerotic plaques. Emphasis is placed on the translational research potential of TR-LIFS and FLIM and on determining whether intrinsic fluorescence signals can be used to provide useful contrast for the diagnosis of high-risk atherosclerotic plaque. Our results demonstrate that these techniques allow for the discrimination of important biochemical features involved in atherosclerotic plaque instability and rupture and show their potential for future intravascular applications. (C) 2010 Society of Photo-Optical Instrumentation Engineers. [DOI: 10.1117/1.3327279]
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