期刊
JOURNAL OF BIOMEDICAL OPTICS
卷 15, 期 2, 页码 -出版社
SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS
DOI: 10.1117/1.3365937
关键词
silver; nanoparticles; nanosystem; photoacoustic imaging; ultrasound imaging; therapy; contrast agent; drug delivery; hybrid nanoparticles
资金
- NCI NIH HHS [R21 CA141203, CA141203, R01 CA149740] Funding Source: Medline
- NIBIB NIH HHS [EB008101, R01 EB008101] Funding Source: Medline
- Direct For Mathematical & Physical Scien
- Division Of Chemistry [0821312] Funding Source: National Science Foundation
Due to their optical absorption properties, metallic nanoparticles are excellent photoacoustic imaging contrast agents. A silver nanosystem is presented here as a potential contrast agent for photoacoustic imaging and image-guided therapy. Currently, the nanosystem consists of a porous silver layer deposited on the surface of spherical silica cores ranging in diameter from 180 to 520 nm. The porous nature of the silver layer will allow for release of drugs or other therapeutic agents encapsulated in the core in future applications. In their current PEGylated form, the silver nanosystem is shown to be nontoxic in vitro at concentrations of silver up to 2 mg/ml. Furthermore, the near-infrared absorbance properties of the nanosystem are demonstrated by measuring strong, concentration-dependent photoacoustic signal from the silver nanosystem embedded in an ex vivo tissue sample. Our study suggests that silver nanosystems can be used as multifunctional agents capable of augmenting image-guided therapy techniques. (C) 2010 Society of Photo-Optical Instrumentation Engineers. [DOI: 10.1117/1.3365937]
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