期刊
JOURNAL OF BIOMEDICAL OPTICS
卷 15, 期 3, 页码 -出版社
SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS
DOI: 10.1117/1.3425884
关键词
near-infrared spectroscopy; diffuse optics; diffuse correlation spectroscopy; congenital heart disease; pediatrics; cerebral blood flow
资金
- NIH [HL-57835, NS-60653, NS-45839, RR-02305, EB-007610, HL-077699, HD-26979, NS-52380]
- Thrasher Research Fund [NR 0016]
- Fundacio Cellex Barcelona
- June and Steve Wolfson Family Foundation
- EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT [P30HD026979] Funding Source: NIH RePORTER
- NATIONAL CENTER FOR RESEARCH RESOURCES [P41RR002305] Funding Source: NIH RePORTER
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL077699, R01HL057835] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING [R21EB007610] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF MENTAL HEALTH [R01MH080892] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS060653, P30NS045839, K23NS052380] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF NURSING RESEARCH [Z01NR000016] Funding Source: NIH RePORTER
We employ a hybrid diffuse correlation spectroscopy (DCS) and near-infrared spectroscopy (NIRS) monitor for neonates with congenital heart disease (n=33). The NIRS-DCS device measured changes during hypercapnia of oxyhemoglobin, deoxyhemoglobin, and total hemoglobin concentrations; cerebral blood flow (rCBF(DCS)); and oxygen metabolism (rCMRO(2)). Concurrent measurements with arterial spin-labeled magnetic resonance imaging (rCBF(ASL-MRI), n=12) cross-validate rCBF(DCS) against rCBF(ASL-MRI), showing good agreement (R=0.7, p=0.01). The study demonstrates use of NIRS-DCS on a critically ill neonatal population, and the results indicate that the optical technology is a promising clinical method for monitoring this population. (C) 2010 Society of Photo-Optical Instrumentation Engineers. [DOI: 10.1117/1.3425884]
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据
分享论文
