期刊
JOURNAL OF BIOMEDICAL OPTICS
卷 15, 期 6, 页码 -出版社
SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS
DOI: 10.1117/1.3516594
关键词
vis-NIR spectroscopy; backscattering; tissues; biomedical optics
资金
- National Institute of Health [PO1 CA80139]
- DoD CDMRP [BC093811]
- CDMRP [BC093811, 544948] Funding Source: Federal RePORTER
We demonstrate that morphological features pertinent to a tissue's pathology may be ascertained from localized measures of broadband reflectance, with a mesoscopic resolution (100-mu m lateral spot size) that permits scanning of an entire margin for residual disease. The technical aspects and optimization of a k-nearest neighbor classifier for automated diagnosis of pathologies are presented, and its efficacy is validated in 29 breast tissue specimens. When discriminating between benign and malignant pathologies, a sensitivity and specificity of 91 and 77% was achieved. Furthermore, detailed subtissue-type analysis was performed to consider how diverse pathologies influence scattering response and overall classification efficacy. The increased sensitivity of this technique may render it useful to guide the surgeon or pathologist where to sample pathology for microscopic assessment. (C) 2010 Society of Photo-Optical Instrumentation Engineers, [DOI: 10.1117/1.3516594]
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