期刊
JOURNAL OF BIOMEDICAL OPTICS
卷 15, 期 2, 页码 -出版社
SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS
DOI: 10.1117/1.3333550
关键词
optoacoustic tomography; photoacoustic tomography; thermoacoustic tomography; image reconstruction; variable speed of sound; inhomogeneous; travel times; geometrical acoustics
Previous research correcting for variable speed of sound in photoacoustic tomography (PAT) based on a generalized radon transform (GRT) model assumes first-order geometrical acoustics (GA) approximation. In the GRT model, the pressure is related to the optical absorption, in an acoustically inhomogeneous medium, through integration over nonspherical isochronous surfaces. Previous research based on the GRT model assumes that the path taken by acoustic rays is linear and neglects amplitude perturbations to the measured pressure. We have derived a higher-order GA expression that takes into account the first-order effect in the amplitude of the measured signal and higher-order perturbation to the travel times. The higher-order perturbation to travel time incorporates the effect of ray bending. Incorrect travel times can lead to image distortion and blurring. These corrections are expected to impact image quality and quantitative PAT. We have previously shown that travel-time corrections in 2-D suggest that perceivable differences in the isochronous surfaces can be seen when the second-order travel-time perturbations are taken into account with a 10% speed-of-sound variation. In this work, we develop iterative image reconstruction algorithms that incorporate this higher-order GA approximation assuming that the speed of sound map is known. We evaluate the effect of higher-order GA approximation on image quality and accuracy. (C) 2010 Society or Photo-Optical Instrumentation Engineers. [DOI: 10.1117/1.3333550]
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