期刊
JOURNAL OF BIOMEDICAL OPTICS
卷 15, 期 6, 页码 -出版社
SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS
DOI: 10.1117/1.3514659
关键词
biomedical optics; imaging; technology; radioactive optical imaging; reporter gene; Cerenkov radiation
资金
- National Cancer Institute (NCI) [R21 CA121842]
- China Scholarship Council
Reporter gene/reporter probe technology is one of the most important techniques in molecular imaging. Lately, many reporter gene/reporter probe systems have been coupled to different imaging modalities such as positron emission tomography (PET) and optical imaging (01). It has been recently found that 01 techniques could be used to monitor radioactive tracers in vitro and in living subjects. In this study, we further demonstrate that a reporter gene/nuclear reporter probe system [herpes simplex virus type-1 thymidine kinase (HSV1-tk) and 9-(4-F-18-fluoro3-hydroxymethyl] butyl) guanine ([F-18] FHBG)1 could be successfully imaged by 01 in vitro and in vivo. 01 with radioactive reporter probes will facilitate and broaden the applications of reporter gene/reporter probe techniques in medical research. (C) 2010 Society of Photo-Optical Instrumentation Engineers. [DOI: 10.1117/1.3514659]
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