Laser-induced tissue hyperthermia mediated by gold nanoparticles: toward cancer phototherapy

We describe an application of plasmonic silica/gold nanoshells to produce a controllable laser hyperthermia in tissues with the aim of the enhancement of cancer photothermal therapy. Laser irradiation parameters are optimized on the basis of preliminary experimental studies using a test-tube phantom and laboratory rats. Temperature distributions on the animal skin surface at hypodermic and intramuscular injection of gold nanoparticle suspensions and affectations by the laser radiation are measured in vivo with a thermal imaging system. The results of temperature measurements are compared with tissue histology. (C) 2009 Society of Photo-Optical Instrumentation Engineers. [DOI: 10.1117/1.3122371]