期刊
JOURNAL OF BIOMEDICAL OPTICS
卷 13, 期 5, 页码 -出版社
SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS
DOI: 10.1117/1.2976422
关键词
topographical variation; polarization sensitivity; optical coherence tomography; polarized light microscopy; polarization-sensitive optical coherence tomography; articular cartilage; collagen fibril; phase retardation
资金
- U. S. Air Force Office of Scientific Research
- Medical Free-Electron Laser Program [FA9550-04-1-0101]
- National Center for Research Resources of the National Institutes of Health [RR-01192]
- National Institutes of Health (NIH) [EB-00293, CA-91717]
- Arnold and Mabel Beckman Foundation
- NIH [R01 AR-45172]
- NSF [REU DMR-0552779]
- NATIONAL CANCER INSTITUTE [R01CA091717] Funding Source: NIH RePORTER
- NATIONAL CENTER FOR RESEARCH RESOURCES [P41RR001192] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES [R01AR045172] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING [R01EB000293] Funding Source: NIH RePORTER
To understand the influence of topographical variations in collagen fibril orientation of articular cartilage on optical phase images of polarization-sensitive optical coherence tomography (PS-OCT), we use polarized light microscopy (PLM) to quantify the orientation and phase retardation of the collagen architecture in cartilage at the same locations imaged by PS-OCT. The PS-OCT experiments demonstrate that articular cartilage has normal variations in polarization sensitivity at different locations over an intact bovine tibial plateau. Articular cartilage is not polarization sensitive along the vertical axis on the medial edge and central areas of the joint surface, but becomes polarization sensitive on the lateral edge of the tibia. This difference in optical phase retardation, as demonstrated by PS- OCT, is verified by PLM to be caused by differences in collagen fibril orientation at different locations of the tibial plateau. This study demonstrates that normal topographical variations in the collagen architecture of articular cartilage within a joint have a profound influence on the optical phase retardation detected by PS-OCT imaging, and therefore must be understood and mapped for specific joints before PS-OCT imaging can be used for the evaluation of the health status of individual joint surfaces. (C) 2008 Society of Photo-Optical Instrumentation Engineers.
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