期刊
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
卷 14, 期 4, 页码 802-807出版社
AMER SCIENTIFIC PUBLISHERS
DOI: 10.1166/jbn.2018.2583
关键词
Self-Assembling Peptide; Embryonic Stem Cells; Cell Injection; Injectable Hydrogel; Tissue Mimic
The fabrication of extracellular matrix-mimic hydrogels that can nurture and direct differentiation of embryonic stem cells is an important target for pattern-printed tissue replacement. Another desirable feature for such materials is their ability to be injected and recover their rheological features post-injection, allowing for facile non-invasive implantation. In this report, we demonstrate the ability of a self-assembling peptide hydrogel to support the culture of embryonic stem cells with the potential to direct differentiation. We also show that we can write a functional tissue replacement with a predetermined pattern using our formulation. Our results may lead to in vivo replacement of diseased tissue with a spatially resolved pattern of a regenerative hydrogel.
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