期刊
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
卷 10, 期 12, 页码 3462-3482出版社
AMER SCIENTIFIC PUBLISHERS
DOI: 10.1166/jbn.2014.2036
关键词
Pancreatic Cancer; Targeted Drug Delivery; Nanomedicine; Novel Drug Delivery Systems; Ligand; Nanoparticles
资金
- Science and Engineering Research Board, Department of Science and Technology (DST), New Delhi, India
Pancreatic cancer is usually diagnosed at the advanced stages, responds poorly to the available chemotherapeutics and constitutes the major factor for high mortality rate. Selective delivery of therapeutics to their cellular targets, without side effects is the foremost objective of the current investigations for effective treatment of pancreatic cancer. The development of the drugs which can selectively target pancreatic cancer along with carriers that can deliver drugs specifically to the rapidly dividing cells is considered as magic bullet for the efficient treatment of this fatal disease. This review describes various factors hampering the efficacy of drug targeting to pancreatic cancer including stromal fortress, hypocascularity, hyaluronan and interstitial fluid pressure, and exploration of various cellular targets for the site specific drug delivery. An account of burgeoning applications of novel drug delivery systems including nanoparticles, liposomes, quantum dots, micelles and drug conjugates in the management of pancreatic cancer is also provided. Additionally, potential of target based therapeutic agents and nanomedicines in clinical trials for the pancreatic cancer therapy are highlighted.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据